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???displayArticle.abstract??? Transthyretin (TTR) is an attractive candidate for use in phylogenetic analysis because it is a short, single-copy nuclear gene with regions that are highly conserved across evolutionarily-divergent organisms from Xenopus laevis to Homo sapiens. To explore its utility as a phylogenetic marker, the complete intron one region (789-805 bp) was sequenced in 22 crocodylian species. Detailed analyses of intron 1 resolved the three expected lineages, Alligatorids, Crocodylids, and Gavialids, and offered additional evidence for the utility of synapomorphic indels in elucidating higher-level phylogenetic relationships. When used in conjunction with other genetic and morphological data sets, intron 1 should be a valuable tool in the investigation of other closely related taxa.
Achen,
Transthyretin gene expression in choroid plexus first evolved in reptiles.
1993, Pubmed
Achen,
Transthyretin gene expression in choroid plexus first evolved in reptiles.
1993,
Pubmed
Aldred,
Evolution of shorter and more hydrophilic transthyretin N-termini by stepwise conversion of exon 2 into intron 1 sequences (shifting the 3' splice site of intron 1).
1997,
Pubmed
Brochu,
Morphology, fossils, divergence timing, and the phylogenetic relationships of Gavialis.
1997,
Pubmed
Gatesy,
The rapid accumulation of consistent molecular support for intergeneric crocodylian relationships.
2008,
Pubmed
Gatesy,
Combined support for wholesale taxic atavism in gavialine crocodylians.
2003,
Pubmed
Harshman,
True and false gharials: a nuclear gene phylogeny of crocodylia.
2003,
Pubmed
Hasegawa,
Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.
1985,
Pubmed
Hennebry,
Structural and functional evolution of transthyretin and transthyretin-like proteins.
2006,
Pubmed
Huelsenbeck,
MRBAYES: Bayesian inference of phylogenetic trees.
2001,
Pubmed
Lanave,
A new method for calculating evolutionary substitution rates.
1984,
Pubmed
McAliley,
Are crocodiles really monophyletic?--Evidence for subdivisions from sequence and morphological data.
2006,
Pubmed
Nylander,
AWTY (are we there yet?): a system for graphical exploration of MCMC convergence in Bayesian phylogenetics.
2008,
Pubmed
Posada,
MODELTEST: testing the model of DNA substitution.
1998,
Pubmed
Power,
Evolution of the thyroid hormone-binding protein, transthyretin.
2000,
Pubmed
Prapunpoj,
Crocodile transthyretin: structure, function, and evolution.
2002,
Pubmed
,
Xenbase
Ray,
The crocodilian mitochondrial control region: general structure, conserved sequences, and evolutionary implications.
2002,
Pubmed
Roos,
Extended mitogenomic phylogenetic analyses yield new insight into crocodylian evolution and their survival of the Cretaceous-Tertiary boundary.
2007,
Pubmed
Schrago,
Timing the origin of New World monkeys.
2003,
Pubmed
Steiner,
New DNA data from a transthyretin nuclear intron suggest an Oligocene to Miocene diversification of living South America opossums (Marsupialia: Didelphidae).
2005,
Pubmed
Vélez-Juarbe,
A gharial from the Oligocene of Puerto Rico: transoceanic dispersal in the history of a non-marine reptile.
2007,
Pubmed
Walton,
Evidence from intron 1 of the nuclear transthyretin (Prealbumin) gene for the phylogeny of African mole-rats (Bathyergidae).
2000,
Pubmed
Willis,
Evidence for placing the false gharial (Tomistoma schlegelii) into the family Gavialidae: inferences from nuclear gene sequences.
2007,
Pubmed
