Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-40392
Development October 1, 2009; 136 (19): 3289-99.

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina.

Agathocleous M , Iordanova I , Willardsen MI , Xue XY , Vetter ML , Harris WA , Moore KB .


Abstract
Progenitor cells in the central nervous system must leave the cell cycle to become neurons and glia, but the signals that coordinate this transition remain largely unknown. We previously found that Wnt signaling, acting through Sox2, promotes neural competence in the Xenopus retina by activating proneural gene expression. We now report that Wnt and Sox2 inhibit neural differentiation through Notch activation. Independently of Sox2, Wnt stimulates retinal progenitor proliferation and this, when combined with the block on differentiation, maintains retinal progenitor fates. Feedback inhibition by Sox2 on Wnt signaling and by the proneural transcription factors on Sox2 mean that each element of the core pathway activates the next element and inhibits the previous one, providing a directional network that ensures retinal cells make the transition from progenitors to neurons and glia.

PubMed ID: 19736324
PMC ID: PMC2739145
Article link: Development
Grant support: [+]
Genes referenced: atoh7 casp3.2 cat.2 ccne1 ctnnb1 ebf3 elavl3 lef1 mapre3 notch1 pcna pou4f1.2 rbpms rbpms2 rlbp1 rpe sox2 tcf3 vsx1 vxn
Antibodies: Ccna2 Ab1 Pcna Ab2 Rlbp1 Ab1 Sox2 Ab2


Article Images: [+] show captions
References:
Baker, 2000, Pubmed, Xenbase [+]


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.0


Major funding for Xenbase is provided by grant P41 HD064556