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XB-ART-40406
Dev Dyn October 1, 2009; 238 (10): 2522-9.

Myosin-X is required for cranial neural crest cell migration in Xenopus laevis.

Hwang YS , Luo T , Xu Y , Sargent TD .


Abstract
Myosin-X (MyoX) belongs to a large family of unconventional, nonmuscle, actin-dependent motor proteins. We show that MyoX is predominantly expressed in cranial neural crest (CNC) cells in embryos of Xenopus laevis and is required for head and jaw cartilage development. Knockdown of MyoX expression using antisense morpholino oligonucleotides resulted in retarded migration of CNC cells into the pharyngeal arches, leading to subsequent hypoplasia of cartilage and inhibited outgrowth of the CNC-derived trigeminal nerve. In vitro migration assays on fibronectin using explanted CNC cells showed significant inhibition of filopodia formation, cell attachment, spreading and migration, accompanied by disruption of the actin cytoskeleton. These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo.

PubMed ID: 19718754
PMC ID: PMC3023993
Article link: Dev Dyn
Grant support: [+]
Genes referenced: actl6a fn1 gal.2 krt70 myo10 myo10.2 myod1 snai2 sox10 sox2 sox9 tbx2
Morpholinos: myo10.2 MO2 myo10.2 MO4


Article Images: [+] show captions
References:
Alfandari, 2003, Pubmed, Xenbase [+]


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