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Dev Dyn June 1, 2009; 238 (6): 1358-65.

Notch signaling downstream of foxD5 promotes neural ectodermal transcription factors that inhibit neural differentiation.

We investigated the role of the Notch signaling pathway in regulating several transcription factors that stabilize a neural fate and expand the neural plate. Increased Notch signaling in a neural lineage via a constitutively activated form (NICD) up-regulated geminin and zic2 in a cell-autonomous manner, and expanded the neural plate domains of sox11, sox2, and sox3. Loss- and gain-of-function assays show that foxD5 acts upstream of notch1 gene expression. Decreasing Notch signaling with an anti-morphic form of a Notch ligand (X-Delta-1(STU)) showed that the foxD5-mediated expansion of the sox gene neural plate domains requires Notch signaling. However, geminin and zic2 appear to be dually regulated by foxD5 and Notch1 signaling. These studies demonstrate that: (1) Notch signaling acts downstream of foxD5 to promote the expression of a subset of neural ectodermal transcription factors; and (2) Notch signaling and the foxD5 transcriptional pathway together maintain the neural plate in an undifferentiated state. Developmental Dynamics 238:1358-1365, 2009. (c) 2009 Wiley-Liss, Inc.

PubMed ID: 19253404
PMC ID: PMC2692561
Article link: Dev Dyn
Grant support: [+]
Genes referenced: dll1 foxd4l1.1 gmnn hes1 notch1 sox11 sox2 sox3 tbx2 zic2

Article Images: [+] show captions
References [+] :
Artavanis-Tsakonas, Notch signaling: cell fate control and signal integration in development. 1999, Pubmed

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