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XB-ART-40470
Dev Dyn June 1, 2009; 238 (6): 1358-65.

Notch signaling downstream of foxD5 promotes neural ectodermal transcription factors that inhibit neural differentiation.



Abstract
We investigated the role of the Notch signaling pathway in regulating several transcription factors that stabilize a neural fate and expand the neural plate. Increased Notch signaling in a neural lineage via a constitutively activated form (NICD) up-regulated geminin and zic2 in a cell-autonomous manner, and expanded the neural plate domains of sox11, sox2, and sox3. Loss- and gain-of-function assays show that foxD5 acts upstream of notch1 gene expression. Decreasing Notch signaling with an anti-morphic form of a Notch ligand (X-Delta-1(STU)) showed that the foxD5-mediated expansion of the sox gene neural plate domains requires Notch signaling. However, geminin and zic2 appear to be dually regulated by foxD5 and Notch1 signaling. These studies demonstrate that: (1) Notch signaling acts downstream of foxD5 to promote the expression of a subset of neural ectodermal transcription factors; and (2) Notch signaling and the foxD5 transcriptional pathway together maintain the neural plate in an undifferentiated state. Developmental Dynamics 238:1358-1365, 2009. (c) 2009 Wiley-Liss, Inc.

PubMed ID: 19253404
PMC ID: PMC2692561
Article link: Dev Dyn
Grant support: [+]
Genes referenced: dll1 foxd4l1.1 gmnn hes1 notch1 sox11 sox2 sox3 tbx2 zic2


Article Images: [+] show captions
References [+] :
Artavanis-Tsakonas, Notch signaling: cell fate control and signal integration in development. 1999, Pubmed


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