Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
FEBS Lett
2009 Sep 03;58317:2779-84. doi: 10.1016/j.febslet.2009.07.019.
Show Gene links
Show Anatomy links
The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.
Bukiya AN
,
Liu J
,
Dopico AM
.
???displayArticle.abstract???
Ethanol-induced inhibition of myocyte large conductance, calcium- and voltage-gated potassium (BK) current causes cerebrovascular constriction, yet the molecular targets mediating EtOH action remain unknown. Using BK channel-forming (cbv1) subunits from cerebral artery myocytes, we demonstrate that EtOH potentiates and inhibits current at Ca(i)(2+) lower and higher than approximately 15 microM, respectively. By increasing cbv1's apparent Ca(i)(2+)-sensitivity, accessory BK beta(1) subunits shift the activation-to-inhibition crossover of EtOH action to <3 microM Ca(i)(2+), with consequent inhibition of current under conditions found during myocyte contraction. Knocking-down KCNMB1 suppresses EtOH-reduction of arterial myocyte BK current and vessel diameter. Therefore, BK beta(1) is the molecular effector of alcohol-induced BK current inhibition and cerebrovascular constriction.
???displayArticle.pubmedLink???
19616547
???displayArticle.pmcLink???PMC2769078 ???displayArticle.link???FEBS Lett ???displayArticle.grants???[+]
Altura,
Alcohol, the cerebral circulation and strokes.
1984, Pubmed
Altura,
Alcohol, the cerebral circulation and strokes.
1984,
Pubmed
Anderson,
The risk of alcohol.
1993,
Pubmed
Belin de Chantemèle,
Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.
2008,
Pubmed
Brenner,
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.
2000,
Pubmed
Brodie,
Ethanol interactions with calcium-dependent potassium channels.
2007,
Pubmed
Bukiya,
Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries.
2007,
Pubmed
Christie,
Alcohol consumption and cerebral blood flow among older adults.
2008,
Pubmed
Cox,
Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity.
2000,
Pubmed
,
Xenbase
Dopico,
Ethanol sensitivity of BK(Ca) channels from arterial smooth muscle does not require the presence of the beta 1-subunit.
2003,
Pubmed
,
Xenbase
Dopico,
Membrane stretch directly activates large conductance Ca(2+)-activated K+ channels in mesenteric artery smooth muscle cells.
1994,
Pubmed
Dopico,
Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminals.
1996,
Pubmed
Dopico,
Ethanol increases the activity of Ca(++)-dependent K+ (mslo) channels: functional interaction with cytosolic Ca++.
1998,
Pubmed
,
Xenbase
Gourley,
Characteristics of reactive hyperemia in the cerebral circulation.
1984,
Pubmed
Jaggar,
Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels.
2005,
Pubmed
Jaggar,
Calcium sparks in smooth muscle.
2000,
Pubmed
Knot,
Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure.
1998,
Pubmed
Kuhlmann,
Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions.
2004,
Pubmed
Liu,
Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction.
2004,
Pubmed
Liu,
Ethanol modulates BKCa channels by acting as an adjuvant of calcium.
2008,
Pubmed
,
Xenbase
Martin,
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol.
2008,
Pubmed
McManus,
Functional role of the beta subunit of high conductance calcium-activated potassium channels.
1995,
Pubmed
,
Xenbase
Nimigean,
Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism.
2000,
Pubmed
Orio,
New disguises for an old channel: MaxiK channel beta-subunits.
2002,
Pubmed
Papassotiriou,
Endothelial K(+) channel lacks the Ca(2+) sensitivity-regulating beta subunit.
2000,
Pubmed
Plüger,
Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure.
2000,
Pubmed
Pérez,
Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle.
2001,
Pubmed
Reynolds,
Alcohol consumption and risk of stroke: a meta-analysis.
2003,
Pubmed
Salkoff,
High-conductance potassium channels of the SLO family.
2006,
Pubmed
Wellman,
Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channels.
2003,
Pubmed
