XB-ART-40744
Blood
January 28, 2010;
115
(4):
906-9.
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
Norrmén C
,
Vandevelde W
,
Ny A
,
Saharinen P
,
Gentile M
,
Haraldsen G
,
Puolakkainen P
,
Lukanidin E
,
Dewerchin M
,
Alitalo K
,
Petrova TV
.
The lymphatic
vasculature is important for the regulation of
tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human
intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin beta1, a member of the family of
LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic
vasculature in vivo, and show that it plays an important role in the maintenance of
lymphatic vessel integrity in Xenopus tadpoles.
PubMed ID:
19965622
PMC ID:
PMC2815506
Article link:
Blood
Grant support:
[+]
Species referenced:
Xenopus laevis
Genes referenced:
ppfibp1
ptprf
Morpholinos:
ppfibp1 MO1
ppfibp1 MO2
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