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XB-ART-4096
Gene February 4, 2004; 326 59-66.

The SNF2 domain protein family in higher vertebrates displays dynamic expression patterns in Xenopus laevis embryos.

Linder B , Cabot RA , Schwickert T , Rupp RA .


Abstract
All eukaryotes share a common nuclear infrastructure, in which DNA is packaged into nucleosomal chromatin. Its functional states, in particular the accessibility of the chromatin fiber to trans-acting factors, are determined by two classes of evolutionarily conserved enzymes, i.e. histone modifying enzymes and ATP-driven nucleosome remodeling machines. Browsing the annotated human genome database, we establish here a family of SNF2-like nuclear ATPases, which are the core enzymatic subunits of chromatin remodeling protein complexes. Homologues of those human genes are also to a large extent found in the Xenopus laevis genome, indicating a high degree of sequence conservation of this family among vertebrates. Expression analyses of the ATPase family of proteins reveal stage- and tissue-specific domains of peak RNA expression during early frog embryogenesis. These dynamic expression profiles suggest specific functional requirements for individual members of this family throughout early stages of vertebrate development.

PubMed ID: 14729263
Article link: Gene

Genes referenced: atrx btaf1 chd1 chd2 chd3 chd4 chd5 chd6 chd7 chd8 crebbp ep400 foxe1 hells hltf ino80 rad54l rad54l2 smarca2 smarca4 smarca5 smarcad1 smarcal1 srcap ttf2


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