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J Biol Chem
2010 Jan 08;2852:1016-22. doi: 10.1074/jbc.M109.029165.
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Involvement of the calcium-sensing receptor in human taste perception.
Ohsu T
,
Amino Y
,
Nagasaki H
,
Yamanaka T
,
Takeshita S
,
Hatanaka T
,
Maruyama Y
,
Miyamura N
,
Eto Y
.
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By human sensory analyses, we found that various extracellular calcium-sensing receptor (CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste themselves. These characteristics are known as "kokumi taste" and often appear in traditional Japanese cuisine. Although GSH is a typical kokumi taste substance (taste enhancer), its mode of action is poorly understood. Here, we demonstrate how the kokumi taste is enhanced by the CaSR, a close relative of the class C G-protein-coupled receptors T1R1, T1R2, and T1R3 (sweet and umami receptors). We identified a large number of CaSR agonist gamma-glutamyl peptides, including GSH (gamma-Glu-Cys-Gly) and gamma-Glu-Val-Gly, and showed that these peptides elicit the kokumi taste. Further analyses revealed that some known CaSR agonists such as Ca(2+), protamine, polylysine, L-histidine, and cinacalcet (a calcium-mimetic drug) also elicit the kokumi taste and that the CaSR-specific antagonist, NPS-2143, significantly suppresses the kokumi taste. This is the first report indicating a distinct function of the CaSR in human taste perception.
Aaslyng,
Chemical and Sensory Characterization of Hydrolyzed Vegetable Protein, a Savory Flavoring.
1998, Pubmed
Aaslyng,
Chemical and Sensory Characterization of Hydrolyzed Vegetable Protein, a Savory Flavoring.
1998,
Pubmed
Adler,
A novel family of mammalian taste receptors.
2000,
Pubmed
Brown,
Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
1993,
Pubmed
,
Xenbase
Brown,
Extracellular calcium sensing and extracellular calcium signaling.
2001,
Pubmed
Chandrashekar,
T2Rs function as bitter taste receptors.
2000,
Pubmed
Chattopadhyay,
Calcium-sensing receptor: roles in and beyond systemic calcium homeostasis.
1997,
Pubmed
Conigrave,
Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology.
2006,
Pubmed
Conigrave,
L-amino acid sensing by the extracellular Ca2+-sensing receptor.
2000,
Pubmed
Conigrave,
Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors.
2006,
Pubmed
Dunkel,
Molecular and sensory characterization of gamma-glutamyl peptides as key contributors to the kokumi taste of edible beans (Phaseolus vulgaris L.).
2007,
Pubmed
Hebert,
Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract.
2004,
Pubmed
Hoon,
Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity.
1999,
Pubmed
Ishimaru,
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
2006,
Pubmed
Kanazawa,
Identification of gamma-glutamylserine, gamma-glutamylalanine, gamma-glutamylvaline and S-methylglutathione of bovine brain.
1965,
Pubmed
Li,
Glutathione: a review on biotechnological production.
2004,
Pubmed
McCaughey,
Calcium deprivation increases the palatability of calcium solutions in rats.
2005,
Pubmed
Nelson,
Mammalian sweet taste receptors.
2001,
Pubmed
Nelson,
An amino-acid taste receptor.
2002,
Pubmed
Reed,
Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains.
2003,
Pubmed
Rodriguez,
The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism.
2005,
Pubmed
Rotin,
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
1994,
Pubmed
Rybczynska,
Hypertensive effect of calcilytic NPS 2143 administration in rats.
2006,
Pubmed
San Gabriel,
The calcium-sensing receptor in taste tissue.
2009,
Pubmed
Toelstede,
A series of kokumi peptides impart the long-lasting mouthfulness of matured Gouda cheese.
2009,
Pubmed
Tordoff,
Involvement of T1R3 in calcium-magnesium taste.
2008,
Pubmed
Tordoff,
Calcium taste preferences: genetic analysis and genome screen of C57BL/6J x PWK/PhJ hybrid mice.
2008,
Pubmed
Ueda,
Flavor characteristics of glutathione in raw and cooked foodstuffs.
1997,
Pubmed
Wang,
Activation of family C G-protein-coupled receptors by the tripeptide glutathione.
2006,
Pubmed
Wellendorph,
The rat GPRC6A: cloning and characterization.
2007,
Pubmed
