Dev Growth Differ 2010 May 01;524:365-76. doi: 10.1111/j.1440-169X.2010.01176.x.

Neurogenesis during optic tectum regeneration in Xenopus laevis.

???displayArticle.abstract???
The regenerative neurogenesis of the optic tectum of larval Xenopus laevis has been studied analyzing the proliferative and morphogenetic phases of the regeneration process after removal of one optic lobe. To this end, short-term and long-term pulses were carried out using the thymidine analog BrdU, selectively incorporated into cells during the S phase of the cell cycle. Results indicate that while in early larvae (stage 49/50, according to Nieuwkoop & Faber 1967) regeneration occurs mainly at the expense of the stem cells present in extensive proliferation zones ("matrix areas") of the midbrain, in late larvae (stage 55/56) regeneration occurs at the expense of stem cells present in very limited matrix areas of the brain and of quiescent cells, which re-enter the cell cycle following trauma. Moreover, in early larvae, morphogenesis of the optic tectum is carried out according to a precise spatio-temporal order from rostro-caudal to latero-medial. By contrast, in late larvae, the topographical order of the regenerative morphogenesis of the optic lobe is completely altered. As a consequence, the regenerated optic tectum in early larvae has an apparently normal structure, while the regenerated optic tectum in late larvae lacks stratification.

???displayArticle.pubmedLink??? 20500763
???displayArticle.link??? Dev Growth Differ