Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Comp Biochem Physiol Part D Genomics Proteomics
2010 Sep 01;53:217-26. doi: 10.1016/j.cbd.2010.05.004.
Show Gene links
Show Anatomy links
Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo).
Holmes RS
,
Cox LA
,
VandeBerg JL
.
???displayArticle.abstract???
At least six families of mammalian acid lipases (E.C. 3.1.1.-) catalyse the hydrolysis of triglycerides in the body, designated as LIPA (lysosomal), LIPF (gastric), LIPJ (testis) and LIPK, LIPM and LIPN (epidermal), which belong to the AB hydrolase superfamily. In this study, in silico methods were used to predict the amino acid sequences, secondary and tertiary structures, and gene locations for acid lipase genes and encoded proteins using data from several mammalian genome projects. Mammalian acid lipase genes were located within a gene cluster for each of the 8 mammalian genomes examined, including human (Homo sapiens), chimpanzee (Pons troglodytes), rhesus monkey (Macacca mulatta), mouse (Mus musculus), rat (Rattus norvegicus), cow (Bos taurus), horse (Equus caballus) and dog (Canis familaris), with each containing 9 coding exons. Human and mouse acid lipases shared 44-87% sequence identity and exhibited sequence alignments and identities for key amino acid residues and conservation of predicted secondary and tertiary structures with those previously reported for human gastric lipase (LIPF) (Roussel et al., 1999). Evidence for a new family of acid lipase genes is reported for mouse and rat genomes, designated as Lipo. Mouse acid lipase genes are subject to differential mRNA tissue expression, with Lipa showing wide tissue expression, while others have a more restricted tissue expression in the digestive tract (Lipf), salivary gland (Lipo) and epidermal tissues (Lipk, Lipm and Lipn). Phylogenetic analyses of the mammalian acid lipase gene families suggested that these genes are products of gene duplication events prior to eutherian mammalian evolution and derived from an ancestral vertebrate LIPA gene, which is present in the frog, Xenopus tropicalis.
Altschul,
Basic local alignment search tool.
1990, Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Ameis,
Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase.
1994,
Pubmed
Anderson,
Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases.
1991,
Pubmed
Anderson,
Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease.
1994,
Pubmed
Assmann,
Positional specificity of triglyceride lipases in post-heparin plasma.
1973,
Pubmed
Baranski,
Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting.
1991,
Pubmed
,
Xenbase
Bodmer,
Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.
1987,
Pubmed
Carninci,
The transcriptional landscape of the mammalian genome.
2005,
Pubmed
Chenna,
Multiple sequence alignment with the Clustal series of programs.
2003,
Pubmed
Chimpanzee Sequencing and Analysis Consortium,
Initial sequence of the chimpanzee genome and comparison with the human genome.
2005,
Pubmed
Deloukas,
The DNA sequence and comparative analysis of human chromosome 10.
2004,
Pubmed
Donoghue,
Rocks and clocks: calibrating the Tree of Life using fossils and molecules.
2007,
Pubmed
Du,
Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein.
1996,
Pubmed
Emanuelsson,
Locating proteins in the cell using TargetP, SignalP and related tools.
2007,
Pubmed
Felsenstein,
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.
1985,
Pubmed
Gerhard,
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
2004,
Pubmed
,
Xenbase
Gibbs,
Evolutionary and biomedical insights from the rhesus macaque genome.
2007,
Pubmed
Gibbs,
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
2004,
Pubmed
Goldstein,
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.
1975,
Pubmed
Guex,
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
1997,
Pubmed
Hirata,
Cloning of a unique lipase from endothelial cells extends the lipase gene family.
1999,
Pubmed
Hoeg,
Cholesteryl ester storage disease and Wolman disease: phenotypic variants of lysosomal acid cholesteryl ester hydrolase deficiency.
1984,
Pubmed
Horton,
Better prediction of protein cellular localization sites with the k nearest neighbors classifier.
1997,
Pubmed
Jaye,
A novel endothelial-derived lipase that modulates HDL metabolism.
1999,
Pubmed
Kent,
The human genome browser at UCSC.
2002,
Pubmed
Kopp,
The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models.
2004,
Pubmed
Lander,
Initial sequencing and analysis of the human genome.
2001,
Pubmed
Lohse,
Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: identification of the catalytically active serine, aspartic acid, and histidine residues.
1997,
Pubmed
Lowe,
Cloning and characterization of human pancreatic lipase cDNA.
1989,
Pubmed
Martin,
Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase.
1988,
Pubmed
McGuffin,
The PSIPRED protein structure prediction server.
2000,
Pubmed
Patrick,
Deficiency of an acid lipase in Wolman's disease.
1969,
Pubmed
Roussel,
Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest.
1999,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Sleat,
Identification of sites of mannose 6-phosphorylation on lysosomal proteins.
2006,
Pubmed
Thierry-Mieg,
AceView: a comprehensive cDNA-supported gene and transcripts annotation.
2006,
Pubmed
Toulza,
Large-scale identification of human genes implicated in epidermal barrier function.
2007,
Pubmed
Van de Peer,
TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment.
1994,
Pubmed
Wang,
Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters.
2008,
Pubmed
Waterston,
Initial sequencing and comparative analysis of the mouse genome.
2002,
Pubmed
Wion,
Human lipoprotein lipase complementary DNA sequence.
1987,
Pubmed
Woodburne,
The evolution of tribospheny and the antiquity of mammalian clades.
2003,
Pubmed