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Chromosome Res
2006 Jan 01;143:319-32. doi: 10.1007/s10577-006-1049-2.
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Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis.
Magnaghi-Jaulin L
,
Jaulin C
.
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Chromosome condensation is thought to be an essential step for the faithful transmission of genetic information during cellular division or gamete formation. The folding of DNA into metaphase chromosomes and its partition during the cell cycle remains a fundamental cellular process that, at the molecular level, is poorly understood. Particularly, the role of histone deacetylase (HDAC) activities in establishing and maintaining meiotic metaphase chromosome condensation has been little documented. In order to better understand how metaphase chromosome condensation is achieved during meiosis, we explored, in vivo, the consequences of HDAC activities inhibition in a Xenopus oocyte model. Our results show that deacetylase activity plays a crucial role in chromosome condensation. This activity is necessary for correct chromosome condensation since the earlier stages of meiosis, but dispensable for meiosis progression, meiosis exit and mitosis entry. We show that HDAC activity correlates with chromosome condensation, being higher when chromosomes are fully condensed and lower during interphase, when chromosomes are decondensed. In addition, we show that, unlike histone H4, Xenopus maternal histone H3 is stored in the oocyte as a hypoacetylated form and is rapidly acetylated when the oocyte exits meiosis.
Abrieu,
Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.
2001, Pubmed,
Xenbase
Abrieu,
Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.
2001,
Pubmed
,
Xenbase
Almouzni,
Histone acetylation influences both gene expression and development of Xenopus laevis.
1994,
Pubmed
,
Xenbase
Astrand,
Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure.
2004,
Pubmed
,
Xenbase
Bannister,
Regulation of gene expression by transcription factor acetylation.
2000,
Pubmed
Bird,
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.
2002,
Pubmed
Brehm,
Retinoblastoma protein recruits histone deacetylase to repress transcription.
1998,
Pubmed
Chen,
Characterization of spindle assembly checkpoint in Xenopus egg extracts.
1997,
Pubmed
,
Xenbase
Choy,
NuA4 subunit Yng2 function in intra-S-phase DNA damage response.
2002,
Pubmed
Cimini,
Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects.
2003,
Pubmed
Dimitrov,
Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type.
1993,
Pubmed
,
Xenbase
Earnshaw,
Topoisomerase II is a structural component of mitotic chromosome scaffolds.
1985,
Pubmed
Ekwall,
Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres.
1997,
Pubmed
Fissore,
Intracellular Ca2+ response of rabbit oocytes to electrical stimulation.
1992,
Pubmed
Formosa,
Changing the DNA landscape: putting a SPN on chromatin.
2003,
Pubmed
Gall,
Structure in the amphibian germinal vesicle.
2004,
Pubmed
,
Xenbase
Gard,
Microtubule organization during maturation of Xenopus oocytes: assembly and rotation of the meiotic spindles.
1992,
Pubmed
,
Xenbase
Gasser,
Metaphase chromosome structure. Involvement of topoisomerase II.
1986,
Pubmed
Gerhart,
Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.
1984,
Pubmed
,
Xenbase
Kusch,
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions.
2004,
Pubmed
Losada,
Dynamic molecular linkers of the genome: the first decade of SMC proteins.
2005,
Pubmed
Magnaghi-Jaulin,
Retinoblastoma protein represses transcription by recruiting a histone deacetylase.
1998,
Pubmed
Morgan,
Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function.
2002,
Pubmed
Murray,
Cell cycle extracts.
1991,
Pubmed
Nebreda,
Regulation of the meiotic cell cycle in oocytes.
2000,
Pubmed
,
Xenbase
Nicolas,
RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.
2000,
Pubmed
Nowak,
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation.
2004,
Pubmed
Nurse,
Universal control mechanism regulating onset of M-phase.
1990,
Pubmed
Ohsumi,
Meiosis-specific cell cycle regulation in maturing Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Peter,
The APC is dispensable for first meiotic anaphase in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Qiu,
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.
2000,
Pubmed
Ryan,
Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity.
1999,
Pubmed
,
Xenbase
Smillie,
Nuclear import and activity of histone deacetylase in Xenopus oocytes is regulated by phosphorylation.
2004,
Pubmed
,
Xenbase
Swedlow,
The making of the mitotic chromosome: modern insights into classical questions.
2003,
Pubmed
Taddei,
Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases.
2001,
Pubmed
Thomson,
The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase.
1999,
Pubmed
Verdone,
Role of histone acetylation in the control of gene expression.
2005,
Pubmed
Xie,
Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.
2002,
Pubmed
