XB-ART-41813Science. September 10, 2010; 329 (5997): 1337-40.
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.
The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos. We also linked mutations in human Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis. These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease.
PubMed ID: 20671153
PMC ID: PMC3509789
Article link: Science.
Grant support: R01 DK075972-06 NIDDK NIH HHS , R01 HD042601-10 NICHD NIH HHS , Howard Hughes Medical Institute , P50 MH094268 NIMH NIH HHS, R01 DK072301 NIDDK NIH HHS , R01 DK072301-08 NIDDK NIH HHS , R01 DK075972 NIDDK NIH HHS , R01 HD042601 NICHD NIH HHS , G0700073 Medical Research Council , R01 GM121317 NIGMS NIH HHS , R01 GM074104 NIGMS NIH HHS , MRC_G0700073 Medical Research Council
Genes referenced: wdpcp
Antibodies referenced: Tuba4b Ab2 Wdpcp Ab1
OMIMs referenced: BARDET-BIEDL SYNDROME; BBS BARDET-BIEDL SYNDROME 1, INCLUDED; BBS1, INCLUDED;; BARDET-BIEDL SYNDROME 2, INCLUDED; BBS2, INCLUDED;; BARDET-BIEDL SYNDROME 3, INCLUDED; BBS3, INCLUDED;; BARDET-BIEDL SYNDROME 4, INCLUDED; BBS4, INCLUDED;; BARDET-BIEDL SYNDROME 5, INCLUDED; BBS5, INCLUDED;; BARDET-BIEDL SYNDROME 6, INCLUDED; BBS6, INCLUDED;; BARDET-BIEDL SYNDROME 7, INCLUDED; BBS7, INCLUDED;; BARDET-BIEDL SYNDROME 8, INCLUDED; BBS8, INCLUDED;; BARDET-BIEDL SYNDROME 9, INCLUDED; BBS9, INCLUDED;; BARDE