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Dev Cell August 17, 2010; 19 (2): 190-2.

On the fast track to organizer gene expression.

Many embryonic species are initially transcriptionally quiescent after fertilization. In this issue of Developmental Cell, Blythe et al. reveal that beta-catenin acts very early in Xenopus development to specifically modify the chromatin of organizer genes, poising them for rapid activation when transcription begins.

PubMed ID: 20708581
PMC ID: PMC5568668
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: nodal5 nodal6 tbx2

References [+] :
Belenkaya, pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. 2002, Pubmed, Xenbase