XB-ART-41933Dev Cell August 17, 2010; 19 (2): 190-2.
On the fast track to organizer gene expression.
Many embryonic species are initially transcriptionally quiescent after fertilization. In this issue of Developmental Cell, Blythe et al. reveal that beta-catenin acts very early in Xenopus development to specifically modify the chromatin of organizer genes, poising them for rapid activation when transcription begins.
PubMed ID: 20708581
PMC ID: PMC5568668
Article link: Dev Cell
Genes referenced: nodal5 nodal6 tbx2
References [+] :
Belenkaya, pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. 2002, Pubmed, Xenbase