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XB-ART-42112
Nat Chem Biol. November 1, 2010; 6 (11): 829-36.

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Thorne CA , Hanson AJ , Schneider J , Tahinci E , Orton D , Cselenyi CS , Jernigan KK , Meyers KC , Hang BI , Waterson AG , Kim K , Melancon B , Ghidu VP , Sulikowski GA , LaFleur B , Salic A , Lee LA , Miller DM , Lee E .


Abstract


PubMed ID: 20890287
PMC ID: PMC3681608
Article link: Nat Chem Biol.
Grant support: 1 R01 GM081635-01 NIGMS NIH HHS , 1 R01 NS26115 NINDS NIH HHS , 5 T 32 DK007563 NIDDK NIH HHS , 5 T32 GM007347 NIGMS NIH HHS , 5 T32 HD007502 NICHD NIH HHS , 5U01 CA084239 NCI NIH HHS , P50 CA95103 NCI NIH HHS , T32 CA09592 NCI NIH HHS , R01 GM081635-05 NIGMS NIH HHS , P30 CA068485 NCI NIH HHS , P30 DK058404 NIDDK NIH HHS , P30 ES000267 NIEHS NIH HHS , P50 GM015431 NIGMS NIH HHS , R01 GM058008 NIGMS NIH HHS , R01 GM081635 NIGMS NIH HHS , R33 CA086243 NCI NIH HHS , U01 CA084239 NCI NIH HHS , R01 GM074044 NIGMS NIH HHS , T32 HD007502 NICHD NIH HHS , P30 ES000267 NIEHS NIH HHS , R33 CA086243 NCI NIH HHS , T32 HD007502 NICHD NIH HHS , P50 CA095103 NCI NIH HHS , R01 NS026115 NINDS NIH HHS , P50 CA95103 NCI NIH HHS , 5 T 32 DK007563 NIDDK NIH HHS , P30 DK058404 NIDDK NIH HHS , 5 T32 GM007347 NIGMS NIH HHS , R01 GM081635 NIGMS NIH HHS , 5 T32 HD007502 NICHD NIH HHS , 1 R01 GM081635-01 NIGMS NIH HHS , P50 GM015431 NIGMS NIH HHS , T32 GM007347 NIGMS NIH HHS , U01 CA084239 NCI NIH HHS , P30 CA068485 NCI NIH HHS , T32 CA009592 NCI NIH HHS , 5U01 CA084239 NCI NIH HHS , T32 CA09592 NCI NIH HHS , 1 R01 NS26115 NINDS NIH HHS

Genes referenced: csnk1a1 krt8 pygo2


References:
Aoki, 1999, Pubmed[+]


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