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XB-ART-42240
Dev Biol. January 15, 2011; 349 (2): 204-12.

The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis.

Abu-Daya A , Nishimoto S , Fairclough L , Mohun TJ , Logan MP , Zimmerman LB .


Abstract
While limb regeneration has been extensively studied in amphibians, little is known about the initial events in limb formation in metamorphosing anurans. The small secreted integrin ligand nephronectin (npnt) is necessary for development of the metanephros in mouse. Although expressed in many tissues, its role in other developmental processes is not well-studied. Here we show that a transgene insertion that disrupts this gene ablates forelimb formation in Xenopus tropicalis. Our results suggest a novel role for integrin signalling in limb development, and represent the first insertional phenotype to be cloned in amphibians.

PubMed ID: 20977901
PMC ID: PMC3021715
Article link: Dev Biol.
Grant support: 1 R01 HD4 2276-01 NICHD NIH HHS , U117560477 Medical Research Council , U117560482 Medical Research Council , U117562103 Medical Research Council , U117560477 Medical Research Council , MC_U117560482 Medical Research Council , 1 R01 HD4 2276-01 NICHD NIH HHS , MC_U117562103 Medical Research Council , R01 HD042276 NICHD NIH HHS , U117560482 Medical Research Council , MC_U117560477 Medical Research Council , U117562103 Medical Research Council , U117560477 Medical Research Council , MRC_MC_U117562103 Medical Research Council , 1 R01 HD4 2276-01 NICHD NIH HHS , MRC_MC_U117560477 Medical Research Council , R01 HD042276 NICHD NIH HHS , U117560482 Medical Research Council , MRC_MC_U117560482 Medical Research Council , U117562103 Medical Research Council , U117560477 Medical Research Council , MC_U117560482 Medical Research Council , 1 R01 HD4 2276-01 NICHD NIH HHS , MC_U117562103 Medical Research Council , R01 HD042276 NICHD NIH HHS , U117560482 Medical Research Council , MC_U117560477 Medical Research Council , U117562103 Medical Research Council

Genes referenced: itga8 itgb1 npnt odc1 pax8 tbx5

Morpholinos referenced: npnt MO1 npnt MO2 npnt MO3

References:
Agarwal, 2002, Pubmed[+]


Article Images: [+] show captions

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