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Cell Adh Migr October 1, 2010; 4 (4): 595-608.

Mechanisms driving neural crest induction and migration in the zebrafish and Xenopus laevis.

Klymkowsky MW , Rossi CC , Artinger KB .

The neural crest is an evolutionary adaptation, with roots in the formation of mesoderm. Modification of neural crest behavior has been is critical for the evolutionary diversification of the vertebrates and defects in neural crest underlie a range of human birth defects. There has been a tremendous increase in our knowledge of the molecular, cellular, and inductive interactions that converge on defining the neural crest and determining its behavior. While there is a temptation to look for simple models to explain neural crest behavior, the reality is that the system is complex in its circuitry. In this review, our goal is to identify the broad features of neural crest origins (developmentally) and migration (cellularly) using data from the zebrafish (teleost) and Xenopus laevis (tetrapod amphibian) in order to illuminate where general mechanisms appear to be in play, and equally importantly, where disparities in experimental results suggest areas of profitable study.

PubMed ID: 20962584
PMC ID: PMC3011258
Article link: Cell Adh Migr
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acad11 admp bmp2 chrd.1 dlx3 dlx5 foxd3 gbx2.1 igfbp5 msx1 msx2 neurod1 neurog1 nodal nog pax3 pax7 prdm1 snai2 sox1 sox10 sox11 sox15 sox2 sox3 sox8 sox9 twist1 wnt8a zic1

Article Images: [+] show captions
References [+] :
Abu-Elmagd, Frizzled7 mediates canonical Wnt signaling in neural crest induction. 2006, Pubmed, Xenbase