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XB-ART-42315
Dev Dyn December 1, 2010; 239 (12): 3436-45.

Xenopus er71 is involved in vascular development.



Abstract
Vasculogenesis and hematopoiesis are closely linked in developing vertebrates. Recently, the existence of a common progenitor of these two tissues, the hemangioblast, has been demonstrated in different organisms. In Xenopus early vascular and hematopoietic cells differentiate in a region called the anterior ventral blood island (aVBI). Differentiating cells from this region migrate out to form embryonic blood and part of the vascular structures of the early frog embryo. A number of members of the ETS family of transcription factors are expressed in endothelial cells and some of them play important roles at various stages of vascular development. The loss of ER71 function in mice led to a complete loss of blood and vascular structures. Similarly, knock down of the zebrafish homolog of er71, etsrp, greatly affected development of vascular structures and myeloid cells. We have identified the Xenopus ortholog of er71 and could show that er71 function in Xenopus is required for vasculogenesis, but not for the development of hematopoietic cells.

PubMed ID: 21069823
Article link: Dev Dyn


Species referenced: Xenopus laevis
Genes referenced: aplnr cdh5 cfd etv2 hbg1 kdr lif lmo1 lmo2 lmo3 mpo pc.1 runx1 tal1
Morpholinos: etv2 MO3 etv2 MO4 etv2 MO5


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