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Dev Cell. January 18, 2011; 20 (1): 19-32.

MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis.

Bonev B , Pisco A , Papalopulu N .

Neural progenitors self-renew and generate neurons throughout the central nervous system. Here, we uncover an unexpected regional specificity in the properties of neural progenitor cells, revealed by the function of a microRNA--miR-9. miR-9 is expressed in neural progenitors, and its knockdown results in an inhibition of neurogenesis along the anterior-posterior axis. However, the underlying mechanism differs--in the hindbrain, progenitors fail to exit the cell cycle, whereas in the forebrain they undergo apoptosis, counteracting the proliferative effect. Among several targets, we functionally identify hairy1 as a primary target of miR-9, regulated at the mRNA level. hairy1 mediates the effects of miR-9 on proliferation, through Fgf8 signaling in the forebrain and Wnt signaling in the hindbrain, but affects apoptosis only in the forebrain, via the p53 pathway. Our findings show a positional difference in the responsiveness of progenitors to miR-9 depletion, revealing an underlying divergence of their properties.

PubMed ID: 21238922
PMC ID: PMC3361082
Article link: Dev Cell.
Grant support: Wellcome Trust , 090868 Wellcome Trust , WT090868 Wellcome Trust

Genes referenced: cdknx fgf8 hes1 mdm2 myt1 neurod1 rpl8 sox3 tp53 tubb2b wnt1 zic1

Morpholinos referenced: hes1 MO1

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Aruga, 2002, Pubmed [+]

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