Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Int J Biol Sci
2011 Apr 15;74:410-7. doi: 10.7150/ijbs.7.410.
Show Gene links
Show Anatomy links
Fishing pluripotency mechanisms in vivo.
Sánchez-Sánchez AV
,
Camp E
,
Mullor JL
.
???displayArticle.abstract???
To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.
Figure 1. Nanog and Oct4 expression during medaka and mouse development. The circular blue arrow indicates the totipotent cycle. Cells and tissues types that express Oct4 or Nanog are boxed in blue when their mRNA expression are detected and/or boxed in green when their protein expressions are detected. Both Nanog and Oct4 have similar expression patterns in medaka and mouse, although mouse Nanog is first detected at the morula stage.
Anderson,
Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis.
2007, Pubmed
Anderson,
Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis.
2007,
Pubmed
Ara,
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).
2003,
Pubmed
Au,
Japanese medaka: a new vertebrate model for studying telomere and telomerase biology.
2009,
Pubmed
Avilion,
Multipotent cell lineages in early mouse development depend on SOX2 function.
2003,
Pubmed
Belting,
spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer.
2001,
Pubmed
Burgess,
The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis.
2002,
Pubmed
Camp,
Nanog regulates proliferation during early fish development.
2009,
Pubmed
Cañón,
Germ cell restricted expression of chick Nanog.
2006,
Pubmed
Chambers,
Nanog safeguards pluripotency and mediates germline development.
2007,
Pubmed
Chambers,
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
2003,
Pubmed
Dann,
Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation.
2008,
Pubmed
Doitsidou,
Guidance of primordial germ cell migration by the chemokine SDF-1.
2002,
Pubmed
Eisen,
Zebrafish as a model system. Perspective.
2003,
Pubmed
Frankenberg,
The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial.
2010,
Pubmed
Gardiner,
Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.
2005,
Pubmed
,
Xenbase
Gardiner,
A global role for zebrafish klf4 in embryonic erythropoiesis.
2007,
Pubmed
Hong,
Activation of the mouse Oct4 promoter in medaka embryonic stem cells and its use for ablation of spontaneous differentiation.
2004,
Pubmed
Hong,
Pluripotency and differentiation of embryonic stem cell lines from the medakafish (Oryzias latipes).
1996,
Pubmed
Huangfu,
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.
2008,
Pubmed
Johnson,
Understanding pluripotency--how embryonic stem cells keep their options open.
2008,
Pubmed
Kamachi,
Involvement of SOX proteins in lens-specific activation of crystallin genes.
1995,
Pubmed
Kawahara,
Critical role of biklf in erythroid cell differentiation in zebrafish.
2001,
Pubmed
Kehler,
Oct4 is required for primordial germ cell survival.
2004,
Pubmed
Knaut,
A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor.
2003,
Pubmed
Kuijk,
A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.
2010,
Pubmed
Kurokawa,
Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes.
2006,
Pubmed
Lau,
Molecular cloning and characterization of the zebrafish (Danio rerio) telomerase catalytic subunit (telomerase reverse transcriptase, TERT).
2008,
Pubmed
Lavial,
The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells.
2007,
Pubmed
,
Xenbase
Lunde,
Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade.
2004,
Pubmed
Mitsui,
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.
2003,
Pubmed
Molyneaux,
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival.
2003,
Pubmed
Morrison,
Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development.
2006,
Pubmed
,
Xenbase
Nakagawa,
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
2008,
Pubmed
Nichols,
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
1998,
Pubmed
Niwa,
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
2000,
Pubmed
Oates,
The zebrafish klf gene family.
2001,
Pubmed
Perrett,
The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture.
2008,
Pubmed
Pesce,
Oct-4: control of totipotency and germline determination.
2000,
Pubmed
Pfennig,
Tert expression and telomerase activity in gonads and somatic cells of the Japanese medaka (Oryzias latipes).
2008,
Pubmed
Prelle,
Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy.
2002,
Pubmed
Reményi,
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers.
2003,
Pubmed
Silva,
Nanog is the gateway to the pluripotent ground state.
2009,
Pubmed
Silva,
Nanog promotes transfer of pluripotency after cell fusion.
2006,
Pubmed
Solter,
From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research.
2006,
Pubmed
Sun,
ES-like cell cultures derived from early zebrafish embryos.
1995,
Pubmed
Sánchez-Sánchez,
Medaka Oct4 is expressed during early embryo development, and in primordial germ cells and adult gonads.
2010,
Pubmed
Sánchez-Sánchez,
Nanog regulates primordial germ cell migration through Cxcr4b.
2010,
Pubmed
Takahashi,
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
2006,
Pubmed
Takeda,
A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development.
1994,
Pubmed
Thermes,
Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation.
2006,
Pubmed
Uwanogho,
Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development.
1995,
Pubmed
Wagner,
STAT3 and SMAD1 signaling in Medaka embryonic stem-like cells and blastula embryos.
2009,
Pubmed
Wakamatsu,
Establishment of a pluripotent cell line derived from a medaka (Oryzias latipes) blastula embryo.
1994,
Pubmed
Wernig,
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
2007,
Pubmed
Wittbrodt,
Medaka--a model organism from the far East.
2002,
Pubmed
Xie,
Structure and function of the smallest vertebrate telomerase RNA from teleost fish.
2008,
Pubmed
Yamaguchi,
Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells.
2009,
Pubmed
Yeom,
Structure, expression and chromosomal location of the Oct-4 gene.
1991,
Pubmed
Yuan,
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995,
Pubmed
Zhang,
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.
2009,
Pubmed
