Nucleosides Nucleotides Nucleic Acids 2011 Apr 01;304:257-63. doi: 10.1080/15257770.2011.580290.

Peptide nucleic acid Pt(II) conjugates: a preliminary study of antisense effects in Xenopus laevis.

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The avid hybridization of peptide nucleic acid (PNA) to DNA and RNA, coupled with the analogue's stability toward enzymatic degradation, has led to its investigation as an antigene/antisense agent. PNA targeted toward the 5'-UTR of an mRNA transcript can effect efficient silencing; however, if targeted to an area within the coding region, the PNA can be displaced by the moving ribosome and be an ineffective antisense agent. Platinum-appended and standard PNAs antisense to an area within the open-reading frame of the gene noggin, were injected into Xenopus laevis embryos. Phenotypic responses were observed and the preliminary results are reported herein.

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Species referenced: Xenopus laevis
Genes referenced: nog