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XB-ART-43308
Development June 1, 2011; 138 (12): 2567-79.

Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus.

Acosta H , López SL , Revinski DR , Carrasco AE .


Abstract
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold''s organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.

PubMed ID: 21610033
Article link: Development

Genes referenced: chrd.1 en2 gsk3b hesx1 hoxb7 myc nodal3.1 nodal3.2 nog notch1 otx2 rbpj smpx tbx2
Morpholinos: notch1 MO1


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