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XB-ART-43330
J Cell Sci November 1, 2010; 123 (Pt 21): 3639-44.

Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.

Gospe SM , Baker SA , Arshavsky VY .


Abstract
Photoreceptors are among the most metabolically active cells in the body, relying on both oxidative phosphorylation and glycolysis to satisfy their high energy needs. Local glycolysis is thought to be particularly crucial in supporting the function of the photoreceptor''s light-sensitive outer segment compartment, which is devoid of mitochondria. Accordingly, it has been commonly accepted that the facilitative glucose transporter Glut1 responsible for glucose entry into photoreceptors is localized in part to the outer segment plasma membrane. However, we now demonstrate that Glut1 is entirely absent from the rod outer segment and is actively excluded from this compartment by targeting information present in its cytosolic C-terminal tail. Our data indicate that glucose metabolized in the outer segment must first enter through other parts of the photoreceptor cell. Consequently, the entire energy supply of the outer segment is dependent on diffusion of energy-rich substrates through the thin connecting cilium that links this compartment to the rest of the cell.

PubMed ID: 20923839
PMC ID: PMC2964109
Article link: J Cell Sci
Grant support: [+]
Genes referenced: actl6a rpe slc2a1


Article Images: [+] show captions
References:
Acosta, 2005, Pubmed [+]


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