Curr Opin Cell Biol 2003 Dec 01;156:654-63. doi: 10.1016/j.ceb.2003.10.010.

Cell-cycle control during meiotic maturation.

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The meiotic cell cycle, which is comprised of two consecutive M-phases, is crucial for the production of haploid germ cells. Although both mitotic and meiotic M-phases share cyclin-B-Cdc2/CDK1 as a key controller, there are meiosis-specific modulations in the regulation of cyclin-B-Cdc2. Recent insights indicate that a common pattern in these modulations can be found by considering the particular activities of mitogen-activated protein kinase (MAPK) during meiosis. The G(2)-phase arrest of meiosis I is released via specific, MAPK-independent signalling that leads to cyclin-B-Cdc2 activation; thereafter, however, the meiotic process is under the control of interplay between MAPK and cyclin-B-Cdc2.

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Species referenced: Xenopus
Genes referenced: cdk1 mapk1