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XB-ART-43468
Pediatr Cardiol April 1, 2010; 31 (3): 335-41.

Examining the cardiac NK-2 genes in early heart development.

Bartlett H , Veenstra GJ , Weeks DL .


Abstract
The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart ("dorsal vessel"), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.

PubMed ID: 19967350
PMC ID: PMC2981039
Article link: Pediatr Cardiol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: nkx2-5
GO keywords: heart development

Disease Ontology terms: congenital heart disease
References [+] :
Akazawa, Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases. 2005, Pubmed