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XB-ART-43832
Dev Dyn June 1, 2011; 240 (6): 1354-64.

Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development.



Abstract
Signaling by the hedgehog (Hh) family of secreted growth factors is essential for development of embryonic blood vessels. Embryos lacking Hh function have abundant endothelial cells but fail to assemble vascular cords or lumenized endothelial tubes. However, the role of Hh signaling during later aspects of vascular patterning and morphogenesis is largely unexplored. We have used small molecule inhibitors and agonists to alter activity of the Hh signaling pathway in the chick embryo. When cyclopamine is added after cord formation, aortal cells form tubes, but these are small and disorganized and the density of the adjacent vascular plexus is reduced. Activation of the Hh pathway with SAG leads to formation of enlarged aortae and increased density of the plexus. The number of endothelial cell filopodia is found to correlate with Hh signaling levels. These studies show that Hh signaling levels must be tightly regulated for normal vascular patterning to be achieved.

PubMed ID: 21384473
PMC ID: PMC4877186
Article link: Dev Dyn
Grant support: [+]
Genes referenced: ihh notch1 ptch1 sag shh vegfa


Article Images: [+] show captions
References [+] :
Britto, A critical role for sonic hedgehog signaling in the early expansion of the developing brain. 2002, Pubmed


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