Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-43952
J Anat 2006 Nov 01;2095:585-95. doi: 10.1111/j.1469-7580.2006.00650.x.
Show Gene links Show Anatomy links

Keystones in lymph node development.

Blum KS , Pabst R .


???displayArticle.abstract???
New molecular markers are constantly increasing our knowledge of developmental processes. In this review article we have attempted to summarize the keystones of lymphoid tissue development in embryonic and pathological conditions. During embryonic lymph node development in the mouse, cells from the anterior cardinal vein start to bud and sprout, forming a lymph sac at defined sites. The protrusion of mesenchymal tissue into the lymph sacs forms the environment, where so-called 'lymphoid tissue inducer cells' and 'mesenchymal organizer cells' meet and interact. Defects of molecules involved in the recruitment and signalling cascades of these cells lead to primary immunodeficiency diseases. A comparison of molecules involved in the development of secondary lymphoid organs and tertiary lymphoid organs, e.g. in autoimmune diseases, shows that the same molecules are involved in both processes. This has led to the hypothesis that the development of tertiary lymphoid organs is a recapitulation of embryonic lymphoid tissue development at ectopic sites.

???displayArticle.pubmedLink??? 17062017
???displayArticle.pmcLink??? PMC2100342
???displayArticle.link??? J Anat


Species referenced: Xenopus
Genes referenced: sacs

References [+] :
Adachi, Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage. 1998, Pubmed