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XB-ART-4400
J Biol Chem 2004 Feb 13;2797:5549-54. doi: 10.1074/jbc.M311332200.
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Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.

Kim LA , Furst J , Butler MH , Xu S , Grigorieff N , Goldstein SA .


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Mammalian voltage-gated K+ channels are assemblies of pore-forming alpha-subunits and modulating beta-subunits. To operate correctly, Kv4 alpha-subunits in the heart and central nervous system require recently identified beta-subunits of the neuronal calcium sensing protein family called K+ channel-interacting proteins (KChIPs). Here, Kv4.2.KChIP2 channels are purified, integrity of isolated complexes confirmed, molar ratio of the subunits determined, and subunit valence established. A complex has 4 subunits of each type, a stoichiometry expected for other channels employing neuronal calcium sensing beta-subunits.

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Species referenced: Xenopus laevis
Genes referenced: kcnd2 kcnip2