Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-4406
Biochem Biophys Res Commun 2003 Nov 21;3113:702-7. doi: 10.1016/j.bbrc.2003.10.053.
Show Gene links Show Anatomy links

Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.

Ku MC , Stewart S , Hata A .


???displayArticle.abstract???
OAZ is a multi zinc finger protein which interacts with several distinct nuclear proteins including Olf-1/EBF, Smad1, and Smad4 and regulates transcription of various genes. Here we show that poly(ADP-ribose) polymerase 1 (Parp1) forms a complex with OAZ and positively regulates BMP-target genes, Xenopus Vent-2 and mouse Smad6 genes. Both wild type and the mutant forms of Parp1, which is deficient in poly(ADP-ribose) polymerase activity, constitutively interact with OAZ; however, the mutant Parp1 did not activate transcription. These results suggest that poly(ADP-ribose) polymerase activity is essential for the transcriptional activation of Vent-2 and Smad6. These results suggest that Parp1 serves as a transcriptional coactivator of OAZ in BMP-dependent gene regulation.

???displayArticle.pubmedLink??? 14623329
???displayArticle.link??? Biochem Biophys Res Commun


Species referenced: Xenopus
Genes referenced: parp1 smad1 smad10 smad4 smad6.2 znf423