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Trends Genet. December 1, 2011; 27 (12): 507-15.

Xenopus research: metamorphosed by genetics and genomics.

Research using Xenopus takes advantage of large, abundant eggs and readily manipulated embryos in addition to conserved cellular, developmental and genomic organization with mammals. Research on Xenopus has defined key principles of gene regulation and signal transduction, embryonic induction, morphogenesis and patterning as well as cell cycle regulation. Genomic and genetic advances in this system, including the development of Xenopus tropicalis as a genetically tractable complement to the widely used Xenopus laevis, capitalize on the classical strengths and wealth of achievements. These attributes provide the tools to tackle the complex biological problems of the new century, including cellular reprogramming, organogenesis, regeneration, gene regulatory networks and protein interactions controlling growth and development, all of which provide insights into a multitude of human diseases and their potential treatments.

PubMed ID: 21963197
PMC ID: PMC3601910
Article link: Trends Genet.
Grant support: DC010210 NIDCD NIH HHS , EY017400 NEI NIH HHS , EY019000 NEI NIH HHS , GM042341 NIGMS NIH HHS , GM049346 NIGMS NIH HHS , GM086321 NIGMS NIH HHS , HD065705 NICHD NIH HHS , HD065713 NICHD NIH HHS , R01 GM042341-26 NIGMS NIH HHS , RR025867 NCRR NIH HHS , P40 RR025867-01A1 NCRR NIH HHS , R01 EY006675-18 NEI NIH HHS , R01 EY017400-01 NEI NIH HHS , R01 EY018000-01A2 NEI NIH HHS , R01 RR013221-02 NCRR NIH HHS , R21 HD065713-01 NICHD NIH HHS , P40 RR025867 NCRR NIH HHS , R01 EY006675 NEI NIH HHS , R01 EY017400 NEI NIH HHS , R01 EY018000 NEI NIH HHS , R01 GM042341 NIGMS NIH HHS , R01 RR013221 NCRR NIH HHS , R21 HD065713 NICHD NIH HHS , R43 EY019000 NEI NIH HHS , R01 HD065705 NICHD NIH HHS , R01 GM086321 NIGMS NIH HHS , R21 DC010210 NIDCD NIH HHS , R44 EY019000 NEI NIH HHS , R01 GM049346 NIGMS NIH HHS

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