Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Cell Calcium. May 1, 2011; 49 (5): 331-40.

Role of IP₃ receptor in development.

IP₃ receptor is a Ca(2+) release channel localized on the endoplasmic reticulum. IP(3) receptor is composed of three isoforms, which are expressed in various cells and tissues, and play variety of roles throughout development. I here describe the role of IP₃ receptor from oogenesis, meiotic maturation and fertilization. I also describe the Ca(2+) signaling at meiosis and mitosis, and especially the role in early embryogenesis to determine dorso-ventral axis formation. Loss of function mutation of type 1 IP₃ receptor in mouse, both by gene targeting and spontaneous mutations shows severe ataxia and other phenotypes. Interestingly, double knockouts of type 1 and type 2 exhibit cardiogenesis arrest and that of type 2 and type 3 results in exocrine secretion deficit. IP₃R of Drosophila or Caenorhabditis elegans is single gene and mutation results severe phenotype of behavior. All the data described here show that IP₃Rs are essential for life and abnormality of IP(3)Rs results in severe abnormality in its structure and function of organism.

PubMed ID: 21596434
Article link: Cell Calcium.

My Xenbase: [ Log-in / Register ]
version: [4.4.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556