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Genesis March 1, 2012; 50 (3): 176-85.

Understanding ciliated epithelia: the power of Xenopus.

Werner ME , Mitchell BJ .

Ciliated epithelia are important in a wide variety of biological contexts where they generate directed fluid flow. Here we address the fundamental advances in understanding ciliated epithelia that have been achieved using Xenopus as a model system. Xenopus embryos are covered with a ciliated epithelium that propels fluid unidirectionally across their surface. The external nature of this tissue, coupled with the molecular tools available in Xenopus and the ease of microscopic analysis on intact animals has thrust Xenopus to the forefront of ciliated epithelia biology. We discuss advances in understanding the molecular regulators of ciliated epithelia cell fate as well as basic aspects of ciliated epithelia cell biology including ciliogenesis and cell polarity.

PubMed ID: 22083727
PMC ID: PMC3294091
Article link: Genesis
Grant support: R01GM089970 NIGMS NIH HHS , R01 GM089970-01A1 NIGMS NIH HHS , R01 GM089970 NIGMS NIH HHS

Genes referenced: actl6a foxi1 foxj1.2 fzd3 notch1 tbx2 vangl2

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