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Genesis
2012 Mar 01;503:176-85. doi: 10.1002/dvg.20824.
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Understanding ciliated epithelia: the power of Xenopus.
Werner ME
,
Mitchell BJ
.
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Ciliated epithelia are important in a wide variety of biological contexts where they generate directed fluid flow. Here we address the fundamental advances in understanding ciliated epithelia that have been achieved using Xenopus as a model system. Xenopus embryos are covered with a ciliated epithelium that propels fluid unidirectionally across their surface. The external nature of this tissue, coupled with the molecular tools available in Xenopus and the ease of microscopic analysis on intact animals has thrust Xenopus to the forefront of ciliated epithelia biology. We discuss advances in understanding the molecular regulators of ciliated epithelia cell fate as well as basic aspects of ciliated epithelia cell biology including ciliogenesis and cell polarity.
Antic,
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.
2010, Pubmed,
Xenbase
Antic,
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.
2010,
Pubmed
,
Xenbase
Avidor-Reiss,
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis.
2004,
Pubmed
Badano,
The ciliopathies: an emerging class of human genetic disorders.
2006,
Pubmed
Cabrera,
Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta.
1990,
Pubmed
Chitnis,
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.
1995,
Pubmed
,
Xenbase
Deblandre,
A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos.
1999,
Pubmed
,
Xenbase
Dubaissi,
Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease.
2011,
Pubmed
,
Xenbase
Ganner,
Regulation of ciliary polarity by the APC/C.
2009,
Pubmed
,
Xenbase
Goodrich,
Principles of planar polarity in animal development.
2011,
Pubmed
Gray,
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.
2009,
Pubmed
,
Xenbase
Gubb,
A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster.
1982,
Pubmed
Hagiwara,
Ciliogenesis in the human oviduct epithelium during the normal menstrual cycle.
1992,
Pubmed
Hayes,
Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development.
2007,
Pubmed
,
Xenbase
Hu,
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.
2010,
Pubmed
Kim,
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.
2010,
Pubmed
,
Xenbase
Lacey,
Cyclin-dependent kinase control of centrosome duplication.
1999,
Pubmed
,
Xenbase
Li,
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
2004,
Pubmed
Lienkamp,
Inversin relays Frizzled-8 signals to promote proximal pronephros development.
2010,
Pubmed
,
Xenbase
Marcet,
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.
2011,
Pubmed
,
Xenbase
May-Simera,
Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.
2010,
Pubmed
Meeks,
Primary ciliary dyskinesia (PCD).
2000,
Pubmed
Mitchell,
A positive feedback mechanism governs the polarity and motion of motile cilia.
2007,
Pubmed
,
Xenbase
Mitchell,
The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin.
2009,
Pubmed
,
Xenbase
Nachury,
Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?
2010,
Pubmed
Nonaka,
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
1998,
Pubmed
Pan,
RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1.
2007,
Pubmed
Panizzi,
New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia.
2007,
Pubmed
Park,
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling.
2006,
Pubmed
,
Xenbase
Park,
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.
2008,
Pubmed
,
Xenbase
Quigley,
Specification of ion transport cells in the Xenopus larval skin.
2011,
Pubmed
,
Xenbase
Sawamoto,
New neurons follow the flow of cerebrospinal fluid in the adult brain.
2006,
Pubmed
Sharpey,
On a Peculiar Motion Excited in Fluids by the Surfaces of Certain Animals.
1830,
Pubmed
Simons,
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.
2005,
Pubmed
,
Xenbase
Steinman,
An electron microscopic study of ciliogenesis in developing epidermis and trachea in the embryo of Xenopus laevis.
1968,
Pubmed
,
Xenbase
Stubbs,
Radial intercalation of ciliated cells during Xenopus skin development.
2006,
Pubmed
,
Xenbase
Stubbs,
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
2008,
Pubmed
,
Xenbase
Tissir,
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
2010,
Pubmed
Vinson,
Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila.
,
Pubmed
Werner,
Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells.
2011,
Pubmed
,
Xenbase
Woerdeman,
[Not Available].
1925,
Pubmed
Yu,
Foxj1 transcription factors are master regulators of the motile ciliogenic program.
2008,
Pubmed
Zeng,
PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.
2010,
Pubmed
