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XB-ART-44557
Genesis March 1, 2012; 50 (3): 251-9.

Xenopus staufen2 is required for anterior endodermal organ formation.



Abstract
Defining the regulatory molecular networks involved in patterning the developing anterior endoderm is essential to understand how the pancreas, liver, stomach, and duodenum are discretely specified from each other. In this study, we analyzed the expression and function of the double-stranded RNA-binding protein Staufen2 in Xenopus laevis endoderm. We found that staufen2 was broadly expressed within the developing endoderm beginning at gastrulation becoming localized to the anterior endoderm at later stages. Through morpholino-mediated knockdown, we demonstrate that Staufen2 function is required for proper formation of the stomach, liver, and pancreas. We define that its function is required during gastrulation for proper patterning of the dorsal-ventral axis and that it acts to regulate expression of BMP signaling components.

PubMed ID: 22162130
PMC ID: PMC3294188
Article link: Genesis
Grant support: [+]
Genes referenced: cer1 chrd.1 gata4 gcg hhex ilf2 ins onecut1 pdia2 pdx1 ptf1a sfrp5 sox17b.2 stau1 stau2 tspan8 ventx2.2
Morpholinos: stau2 MO1


Article Images: [+] show captions
References:
Allison, 2004, Pubmed, Xenbase [+]


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