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XB-ART-44591
Dev Dyn February 1, 2012; 241 (2): 257-69.

ΔNp63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus.

Tríbulo C , Guadalupe Barrionuevo M , Agüero TH , Sánchez SS , Calcaterra NB , Aybar MJ .


Abstract
BACKGROUND: It has been established in several models that the p63 gene has an important role in the development of the epidermis and its derivatives. In Xenopus, only the ΔNp63 isoform of this gene has been cloned and its role during epidermal development remains unknown. RESULTS: In this work, we showed that ΔNp63 is expressed in the nonneural ectoderm since the gastrula stage and that it is regulated by the bone morphogenetic protein 4 (BMP4) signaling pathway. Our in vivo and in vitro experiments demonstrated that ΔNp63 is required in the earliest inductive steps of epidermal development. The overexpression of ΔNp63 caused an increase in epidermal markers with a suppression of neural induction while the blocking of ΔNp63 led to the opposite results. Finally, we found that ΔNp63 acts as an anti-apoptotic gene, regulating the transcription of some apoptotic and anti-apoptotic factors. CONCLUSION: The results suggest that ΔNp63 is an essential gene in early epidermal specification under the control of BMP4.

PubMed ID: 22170861
Article link: Dev Dyn

Genes referenced: ag1 bax bcl2 bmp4 chrd.1 dlx3 dlx5 foxd3 krt12.4 six1 sox2 tbxt tp63
Morpholinos: tp63 MO1


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