The spindle directs chromosome partitioning in eukaryotes and, for the last three decades, has been considered primarily a structure based on microtubules, microtubule motors, and other microtubule binding proteins. However, a surprisingly large body of both old and new studies suggests roles for actin filaments (F-actin) and myosins (F-actin-based motor proteins) in spindle assembly and function. Here we review these data and conclude that in several cases the evidence for the participation of F-actin and myosins in spindle function is very strong, and in the situations where it is less strong, there is nevertheless enough evidence to warrant further investigation.
PubMed ID: 21920311
PMC ID: PMC3197778
Article link: Dev Cell.
Grant support: 5F32GM090674 NIGMS NIH HHS , GM052932 NIGMS NIH HHS , F32 GM090674-02 NIGMS NIH HHS , R01 GM052932-14 NIGMS NIH HHS , R01 GM052932 NIGMS NIH HHS
Genes referenced: actl6a