Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-44712
J Pediatr Hematol Oncol 2009 Dec 01;3112:972-6. doi: 10.1097/MPH.0b013e3181b8701f.
Show Gene links Show Anatomy links

Brainstem glioma presenting as pruritus in children with neurofibromatosis-1.

Darken RS , Bogitch R , Leonard J , Perry A , McKinstry RC , Gutmann DH , Rubin JB .


???displayArticle.abstract???
Children with neurofibromatosis type 1 (NF1) are at increased risk of developing tumors of the nervous system. The most common intracranial tumors are low-grade astrocytomas, which most frequently involve the optic pathway, and less often, the brainstem. In cases of brainstem glioma in NF1, treatment decisions are frequently complicated by the paucity of symptoms referable to the tumor. Here, we describe 2 children with NF1 whose initial presentation of a growing brainstem glioma was localized pruritus. This unusual presentation emphasizes the importance of appreciating subtle, often hard to localize, symptoms in this high-risk population.

???displayArticle.pubmedLink??? 19935099
???displayArticle.link??? J Pediatr Hematol Oncol


Species referenced: Xenopus
Genes referenced: nf1