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XB-ART-44836
Genesis. March 1, 2012; 50 (3): 143-54.

From expression cloning to gene modeling: the development of Xenopus gene sequence resources.



Abstract
The Xenopus community has made concerted efforts over the last 10-12 years systematically to improve the available sequence information for this amphibian model organism ideally suited to the study of early development in vertebrates. Here I review progress in the collection of both sequence data and physical clone reagents for protein coding genes. I conclude that we have cDNA sequences for around 50% and full-length clones for about 35% of the genes in Xenopus tropicalis, and similar numbers but a smaller proportion for Xenopus laevis. In addition, I demonstrate that the gaps in the current genome assembly create problems for the computational elucidation of gene sequences, and suggest some ways to ameliorate the effects of this.

PubMed ID: 22344767
PMC ID: PMC3488295
Article link: Genesis.
Grant support: U117597137 Medical Research Council , MC_U117597137 Medical Research Council , U117597137 Medical Research Council , MRC_MC_U117597137 Medical Research Council , U117597137 Medical Research Council , MC_U117597137 Medical Research Council , U117597137 Medical Research Council

Genes referenced: ids


References:
Agrawal, 2009, Pubmed, Xenbase[+]


Article Images: [+] show captions

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