Carroll TJ , Das A .

R01DK080004 NIDDK NIH HHS

Aigouy, Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. 2010, Pubmed

Aigouy, Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. 2010, Pubmed
Axelrod, Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. 2001, Pubmed
Babayeva, Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. 2011, Pubmed
Bastock, Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning. 2003, Pubmed
Bastos, Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion. 2009, Pubmed
Bayly, Pointing in the right direction: new developments in the field of planar cell polarity. 2011, Pubmed
Bertet, Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation. 2004, Pubmed
Bonnet, Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis. 2009, Pubmed
Boyle, Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. 2007, Pubmed
Brunskill, Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production. 2011, Pubmed
Buechling, Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. 2010, Pubmed , Xenbase
Burn, Calcium/NFAT signalling promotes early nephrogenesis. 2011, Pubmed
Cadigan, Wnt signaling: complexity at the surface. 2006, Pubmed
Cai, G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6. 2005, Pubmed
Camilli, Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression. 2010, Pubmed
Carreira-Barbosa, Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. 2009, Pubmed
Casal, Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. 2006, Pubmed
Chauvet, Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. 2004, Pubmed
Chi, Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. 2009, Pubmed
Choi, Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. 2011, Pubmed
Classen, Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. 2005, Pubmed
Cruciat, Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. 2010, Pubmed , Xenbase
Das, Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. 2004, Pubmed
Deane, Polycystic kidney disease and the renal cilium. 2007, Pubmed
Debiec, Abnormal renal phenotype in L1 knockout mice: a novel cause of CAKUT. 2002, Pubmed
Djiane, Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. 2000, Pubmed , Xenbase
Fanto, The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor. 2003, Pubmed
Feiguin, The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. 2001, Pubmed
Fischer, Defective planar cell polarity in polycystic kidney disease. 2006, Pubmed
Gao, Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. 2011, Pubmed
Goldstein, Wnt signals can function as positional cues in establishing cell polarity. 2006, Pubmed
Goodrich, Principles of planar polarity in animal development. 2011, Pubmed
Goto, Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. 2005, Pubmed , Xenbase
Green, Opposing Wnt pathways orient cell polarity during organogenesis. 2008, Pubmed
Guillaume, Paraxial mesoderm contributes stromal cells to the developing kidney. 2009, Pubmed
Guirao, Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. 2010, Pubmed
Habas, Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. 2003, Pubmed , Xenbase
Habas, Activation of Rho and Rac by Wnt/frizzled signaling. 2006, Pubmed , Xenbase
Hannus, Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. 2002, Pubmed
Happé, Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. 2009, Pubmed
Harrington, Cadherin-mediated adhesion regulates posterior body formation. 2007, Pubmed
Hartleben, Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. 2008, Pubmed
Hartman, Cessation of renal morphogenesis in mice. 2007, Pubmed
Hermle, Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. 2010, Pubmed
Hu, A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. 2010, Pubmed
Humphreys, Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. 2010, Pubmed
Ibraghimov-Beskrovnaya, Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies. 2008, Pubmed
Iizuka-Kogo, Abnormal development of urogenital organs in Dlgh1-deficient mice. 2007, Pubmed
Inoue, C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. 2004, Pubmed
Karner, Planar cell polarity and vertebrate organogenesis. 2006, Pubmed
Karner, Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. 2009, Pubmed , Xenbase
Karner, Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. 2011, Pubmed , Xenbase
Kobayashi, Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. 2008, Pubmed
Lal, Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. 2008, Pubmed
Lawrence, Planar cell polarity: one or two pathways? 2007, Pubmed
Li, Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. 2010, Pubmed
Li, Oriented cell division as a response to cell death and cell competition. 2009, Pubmed
Li, Aberrant planar cell polarity induced by urinary tract obstruction. 2009, Pubmed
Lienkamp, Inversin relays Frizzled-8 signals to promote proximal pronephros development. 2010, Pubmed , Xenbase
Lokmane, vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. 2010, Pubmed
Lu, PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. 2004, Pubmed , Xenbase
Lu, Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. 2004, Pubmed
Luyten, Aberrant regulation of planar cell polarity in polycystic kidney disease. 2010, Pubmed
Ma, Cell packing influences planar cell polarity signaling. 2008, Pubmed
Mao, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. 2011, Pubmed
Marlow, Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. 2002, Pubmed , Xenbase
Marose, Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. 2008, Pubmed , Xenbase
Matakatsu, Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. 2004, Pubmed
Matsui, Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. 2005, Pubmed , Xenbase
Medina, Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. 2004, Pubmed , Xenbase
Meyer, Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. 2004, Pubmed
Meyer, Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. 2006, Pubmed
Michael, A role for microfilament-based contraction in branching morphogenesis of the ureteric bud. 2005, Pubmed
Mikels, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. 2006, Pubmed
Milenkovic, Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. 2009, Pubmed
Mugford, High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. 2009, Pubmed
Müller, Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease. 1999, Pubmed
Naim, Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. 2005, Pubmed
Nauli, Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. 2003, Pubmed
Nauli, Polycystins and mechanosensation in renal and nodal cilia. 2004, Pubmed
Nishio, Loss of oriented cell division does not initiate cyst formation. 2010, Pubmed
O'Connell, The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010, Pubmed
Oishi, The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. 2003, Pubmed , Xenbase
Olsen, Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. 2007, Pubmed
Oteiza, Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. 2010, Pubmed
Otto, Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 2003, Pubmed
Patel, Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. 2008, Pubmed
Peradziryi, PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. 2011, Pubmed , Xenbase
Pope, Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila. 2008, Pubmed
Praetorius, Removal of the MDCK cell primary cilium abolishes flow sensing. 2003, Pubmed
Praetorius, Bending the MDCK cell primary cilium increases intracellular calcium. 2001, Pubmed
Qian, Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. 2005, Pubmed
Rock, Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. 2005, Pubmed
Rohatgi, The ciliary membrane. 2010, Pubmed
Rohatgi, Patched1 regulates hedgehog signaling at the primary cilium. 2007, Pubmed
Romagnolo, Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin. 1999, Pubmed
Saadi-Kheddouci, Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. 2001, Pubmed
Saburi, Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity. 2005, Pubmed
Saburi, Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. 2008, Pubmed
Schlesinger, Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. 1999, Pubmed
Shima, Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. 2002, Pubmed
Simon, Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression. 2004, Pubmed
Simons, Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. 2005, Pubmed , Xenbase
Simons, Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. 2009, Pubmed
Simons, Podocyte polarity signalling. 2009, Pubmed
Skoglund, Integration of planar cell polarity and ECM signaling in elongation of the vertebrate body plan. 2010, Pubmed
Song, A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. 2010, Pubmed
Strutt, Cleavage and secretion is not required for Four-jointed function in Drosophila patterning. 2004, Pubmed
Strutt, Gradients and the specification of planar polarity in the insect cuticle. 2009, Pubmed
Strutt, Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. 2001, Pubmed
Sugiyama, The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice. 2011, Pubmed
Tada, Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. 2000, Pubmed , Xenbase
Takakura, Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. 2009, Pubmed
Tanigawa, Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. 2011, Pubmed
Tao, Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. 2005, Pubmed , Xenbase
Thorpe, Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. 1997, Pubmed
Tree, Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. 2002, Pubmed
Ulrich, Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. 2005, Pubmed
Usui, Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. 1999, Pubmed
Vieira, FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells. 2006, Pubmed
Vincent, Off-track takes Frizzled off the canonical path. 2011, Pubmed , Xenbase
Wallingford, Vertebrate gastrulation: polarity genes control the matrix. 2005, Pubmed , Xenbase
Wallingford, Dishevelled controls cell polarity during Xenopus gastrulation. 2000, Pubmed , Xenbase
Wallingford, Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. 2001, Pubmed , Xenbase
Wallingford, Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. 2011, Pubmed , Xenbase
Wallingford, Convergent extension: the molecular control of polarized cell movement during embryonic development. 2002, Pubmed , Xenbase
Wehrli, Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. 1998, Pubmed
Wilson, Polycystic kidney disease: new understanding in the pathogenesis. 2004, Pubmed
Wilson, Cystic diseases of the kidney: role of adhesion molecules in normal and abnormal tubulogenesis. 1999, Pubmed
Witze, Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. 2008, Pubmed
Yang, Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 2002, Pubmed
Yates, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. 2010, Pubmed
Yu, A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. 2009, Pubmed
Zallen, Multicellular dynamics during epithelial elongation. 2008, Pubmed
Zeidler, Multiple roles for four-jointed in planar polarity and limb patterning. 2000, Pubmed