XB-ART-44972Nat Cell Biol. January 1, 2012; 14 (1): 38-45.
Shaping development with ESCRTs.
Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.
PubMed ID: 22193162
Article link: Nat Cell Biol.