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XB-ART-44974
Genes Dev February 1, 2011; 25 (3): 201-13.

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia.



Abstract
Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.

PubMed ID: 21289065
PMC ID: PMC3034894
Article link: Genes Dev
Grant support: [+]
Genes referenced: shh wls


Article Images: [+] show captions
References:
Adler, 2002, Pubmed [+]


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