XB-ART-44974Genes Dev February 1, 2011; 25 (3): 201-13.
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia.
Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
PubMed ID: 21289065
PMC ID: PMC3034894
Article link: Genes Dev
Genes referenced: shh wls
Article Images: [+] show captions
|Figure 1. Cilia diversity. (A) Transmission electron micros- copy of motile cilia; basal body-associated structures are evi- dent, including the downward-pointing striated rootlets, thought to be platforms for vesicle docking. (B) Cilia in a kidney tubule; defects in kidney cilia are associated with polycystic kidney disease. (C) Motile monocilia in the early embryo gen- erate fluid flow that is essential for normal left/right patterning. Patients with primary ciliary dyskinesia frequently display situs inversus. (D) Cilia in the lumen of the neural tube. (The acet- ylated tubulin immunostaining also highlights axon bundles.) These neural tube cilia are essential for normal Hedgehog- mediated patterning of the CNS. (E) A multiciliated cell. These cells beat directionally to move fluid in the airway, CNS, and oviducts. Defects in these cilia lead to respiratory problems and hydrocephalus. (F) Primary cilia in developing endoderm. Pri- mary cilia in various tissues appear to perform a wide range of sensory functions, and animals with defective cilia display de- fects in the lung, kidney, liver, and heart.|