Wnt signaling: the β-cat(enin)''s meow.
In a study in the December 15, 2011, issue of Genes & Development, Valenta and colleagues (pp. 2631-2643) constructed a series of β-catenin mutants that allowed them to separate β-catenin''s activity as a mediator of Wnt signaling from its activity as cell adhesion component. In doing so, they uncovered some surprising properties of Wnt signaling.
PubMed ID: 22279043
PMC ID: PMC3273833
Article link: Genes Dev.