Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Cell Physiol Biochem
2011 Jan 01;284:613-24. doi: 10.1159/000335757.
Show Gene links
Show Anatomy links
TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.
Limberg SH
,
Netter MF
,
Rolfes C
,
Rinné S
,
Schlichthörl G
,
Zuzarte M
,
Vassiliou T
,
Moosdorf R
,
Wulf H
,
Daut J
,
Sachse FB
,
Decher N
.
???displayArticle.abstract???
BACKGROUND/AIMS: Atrial fibrillation is the most common arrhythmia in the elderly, and potassium channels with atrium-specific expression have been discussed as targets to treat atrial fibrillation. Our aim was to characterize TASK-1 channels in human heart and to functionally describe the role of the atrial whole cell current I(TASK-1).
METHODS AND RESULTS: Using quantitative PCR, we show that TASK-1 is predominantly expressed in the atria, auricles and atrio-ventricular node of the human heart. Single channel recordings show the functional expression of TASK-1 in right human auricles. In addition, we describe for the first time the whole cell current carried by TASK-1 channels (I(TASK-1)) in human atrial tissue. We show that I(TASK-1) contributes to the sustained outward current I(Ksus) and that I(TASK-1) is a major component of the background conductance in human atrial cardiomyocytes. Using patch clamp recordings and mathematical modeling of action potentials, we demonstrate that modulation of I(TASK-1) can alter human atrial action potential duration.
CONCLUSION: Due to the lack of ventricular expression and the ability to alter human atrial action potential duration, TASK-1 might be a drug target for the treatment of atrial fibrillation.
Abbruzzese,
Modification of hERG1 channel gating by Cd2+.
2010, Pubmed,
Xenbase
Abbruzzese,
Modification of hERG1 channel gating by Cd2+.
2010,
Pubmed
,
Xenbase
Barth,
Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature.
2005,
Pubmed
Burashnikov,
New developments in atrial antiarrhythmic drug therapy.
2010,
Pubmed
Bustamante,
Isolation of single atrial and ventricular cells from the human heart.
1982,
Pubmed
Chandler,
Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.
2009,
Pubmed
Chugh,
Epidemiology and natural history of atrial fibrillation: clinical implications.
2001,
Pubmed
Courtemanche,
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.
1998,
Pubmed
Decher,
Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels.
2005,
Pubmed
,
Xenbase
Decher,
Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.
2011,
Pubmed
Dixon,
Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats.
1994,
Pubmed
Donner,
Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability.
2011,
Pubmed
Duprat,
TASK, a human background K+ channel to sense external pH variations near physiological pH.
1997,
Pubmed
,
Xenbase
Ehrlich,
Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?
2009,
Pubmed
Fedida,
Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.
1993,
Pubmed
Gaborit,
Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.
2005,
Pubmed
Goldstein,
Potassium leak channels and the KCNK family of two-P-domain subunits.
2001,
Pubmed
Graham,
Expression of a two-pore domain K+ channel (TASK-1) in developing avian and mouse ventricular conduction systems.
2006,
Pubmed
Guo,
Roles of the voltage-gated K+ channel subunits, Kv 1.5 and Kv 1.4, in the developmental changes of K+ currents in cultured neonatal rat ventricular cells.
1997,
Pubmed
Kim,
TBAK-1 and TASK-1, two-pore K(+) channel subunits: kinetic properties and expression in rat heart.
1999,
Pubmed
Maier,
Stimulation of L-type Ca2+ current in human atrial myocytes by insulin.
1999,
Pubmed
McBride,
The emerging role of antiarrhythmic compounds with atrial selectivity in the management of atrial fibrillation.
2009,
Pubmed
Michael,
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.
2009,
Pubmed
Mitcheson,
A structural basis for drug-induced long QT syndrome.
2000,
Pubmed
,
Xenbase
Musset,
Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons.
2006,
Pubmed
Nattel,
Innovative approaches to anti-arrhythmic drug therapy.
2006,
Pubmed
Nattel,
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.
2007,
Pubmed
Nattel,
Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates.
2010,
Pubmed
Nerbonne,
Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium.
2000,
Pubmed
Nerbonne,
Molecular physiology of cardiac repolarization.
2005,
Pubmed
Putzke,
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.
2007,
Pubmed
,
Xenbase
Snyders,
A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.
1993,
Pubmed
Streit,
A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore.
2011,
Pubmed
,
Xenbase
Van Wagoner,
Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation.
1997,
Pubmed
Wang,
Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.
1993,
Pubmed
Wettwer,
Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation.
2004,
Pubmed
Wilders,
Dynamic clamp: a powerful tool in cardiac electrophysiology.
2006,
Pubmed
