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Mech Dev July 1, 2012; 129 (5-8): 136-46.

Xmab21l3 mediates dorsoventral patterning in Xenopus laevis.

Sridharan J , Haremaki T , Jin Y , Teegala S , Weinstein DC .

Specification of the dorsoventral (DV) axis is critical for the subsequent differentiation of regional fate in the primary germ layers of the vertebrate embryo. We have identified a novel factor that is essential for dorsal development in embryos of the frog Xenopus laevis. Misexpression of Xenopus mab21-like 3 (Xmab21l3) dorsalizes gastrula-stage mesoderm and neurula-stage ectoderm, while morpholino-mediated knockdown of Xmab21l3 inhibits dorsal differentiation of these embryonic germ layers. Xmab21l3 is a member of a chordate-specific subclass of a recently characterized gene family, all members of which contain a conserved, but as yet ill-defined, Mab21 domain. Our studies suggest that Xmab21l3 functions to repress ventralizing activity in the early vertebrate embryo, via regulation of BMP/Smad and Ras/ERK signaling.

PubMed ID: 22609272
PMC ID: PMC3409299
Article link: Mech Dev
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: chrd.1 fgf4 foxi1 gsc lgals4.2 mab21l3 mapk1 sox2 sox3 szl wnt8a
Morpholinos: mab21l3 MO1

Phenotypes: Xla Wt + mab21l3 (fig.3.a) [+]

Article Images: [+] show captions
References [+] :
Baird, Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail. 1992, Pubmed