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XB-ART-45478
Front Endocrinol (Lausanne) January 1, 2010; 1 4.

About a snail, a toad, and rodents: animal models for adaptation research.

Roubos EW , Jenks BG , Xu L , Kuribara M , Scheenen WJ , Kozicz T .


Abstract
Neural adaptation mechanisms have many similarities throughout the animal kingdom, enabling to study fundamentals of human adaptation in selected animal models with experimental approaches that are impossible to apply in man. This will be illustrated by reviewing research on three of such animal models, viz. (1) the egg-laying behavior of a snail, Lymnaea stagnalis: how one neuron type controls behavior, (2) adaptation to the ambient light condition by a toad, Xenopus laevis: how a neuroendocrine cell integrates complex external and neural inputs, and (3) stress, feeding, and depression in rodents: how a neuronal network co-ordinates different but related complex behaviors. Special attention is being paid to the actions of neurochemical messengers, such as neuropeptide Y, urocortin 1, and brain-derived neurotrophic factor. While awaiting new technological developments to study the living human brain at the cellular and molecular levels, continuing progress in the insight in the functioning of human adaptation mechanisms may be expected from neuroendocrine research using invertebrate and vertebrate animal models.

PubMed ID: 22649351
PMC ID: PMC3355873
Article link: Front Endocrinol (Lausanne)

Genes referenced: adcyap1 avp bdnf cartpt cnr1 crh gabarap hpse lep ngfr npy nr3c1 nradd ntrk2 pomc snai1 tbx2 trh ucn1 vipr1


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References [+] :
Asakawa, Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice. 2001, Pubmed


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