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XB-ART-45512
EMBO J January 1, 2012; 31 (12): 2670-84.

Three decades of Wnts: a personal perspective on how a scientific field developed.

Nusse R , Varmus H .


Abstract
Wnt genes and components of Wnt signalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviours to several diseases, especially cancers. Emergence of the field of Wnt signalling can be largely traced back to the discovery of the first mammalian Wnt gene in 1982. In this essay, we mark the thirtieth anniversary of that discovery by describing some of the critical scientific developments that led to the flowering of this field of research.

PubMed ID: 22617420
PMC ID: PMC3380217
Article link: EMBO J

Genes referenced: notch4 notch4.2

References [+] :
Aberle, beta-catenin is a target for the ubiquitin-proteasome pathway. 1997, Pubmed


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