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XB-ART-45671
Dev Dyn February 1, 2012; 241 (2): 294-302.

Hyaluronan is required for cranial neural crest cells migration and craniofacial development.

Casini P , Nardi I , Ori M .


Abstract
Hyaluronan is a crucial glycosaminoglycan of the vertebrate embryonic extracellular matrix able to influence cell behaviour, both by assembling the pericellular matrices and by activating signal transducing receptors such as CD44.We showed that the hyaluronan synthases, Has1 and Has2, and CD44 display a dynamic expression pattern during cranial neural crest cells (NCC) development. By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton.The data suggest that hyaluronan helps to maintain the active migratory behaviour of cranial NCC, and that its presence around pre-chondrogenic NCC is crucial for their survival. CD44 knock down also suggests that the role of hyaluronan in cranial NCC migration could be mediated, at least in part, by the activation of CD44. These findings contribute to the unveiling of the functional relation between NCC and their extracellular environment during craniofacial development.

PubMed ID: 22184056
Article link: Dev Dyn

Genes referenced: cd44 dll4 gal.2 has1 has2 mok slc12a3 snai2
Morpholinos: cd44 MO1 cd44 MO2 has1 MO1 has1 MO2 has2 MO1 has2 MO2


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