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XB-ART-45881
Methods Mol Biol 2012 Jan 01;920:221-43. doi: 10.1007/978-1-61779-998-3_16.
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Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts.

Knipscheer P , Räschle M , Schärer OD , Walter JC .


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Interstrand cross-links (ICL) are one of the most hazardous types of DNA damage as they form a roadblock to all processes that involve strand separation. Repair of these lesions involves several different DNA repair pathways, but the molecular mechanism is unclear. Here we describe a system that allows the examination of ICL repair, via a physiological mechanism, in vitro. This system, which uses Xenopus egg extracts in combination with a DNA template that contains a site-specific ICL, represents a unique tool to study the molecular mechanism of ICL repair.

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References [+] :
Akkari, DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links. 2000, Pubmed