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XB-ART-4600
Development December 1, 2003; 130 (23): 5569-78.

PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development.

Yang J , Wu J , Tan C , Klein PS .


Abstract
The Wnt/beta-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A) has been implicated as a regulator of this pathway. However, this has not been investigated by loss-of-function analyses. Here we report loss-of-function analysis of PP2A:B56epsilon during early Xenopus embryogenesis. We provide direct evidence that PP2A:B56epsilon is required for Wnt/beta-catenin signaling upstream of Dishevelled and downstream of the Wnt ligand. We show that maternal PP2A:B56epsilon function is required for dorsal development, and PP2A:B56epsilon function is required later for the expression of the Wnt target gene engrailed, for subsequent midbrain-hindbrain boundary formation, and for closure of the neural tube. These data demonstrate a positive role for PP2A:B56epsilon in the Wnt pathway.

PubMed ID: 14522869
Article link: Development

Genes referenced: cer1 chrd.1 dkk1 dvl2 egr2 en2 fgf8 gal.2 gsc hes7.1 hoxb9 hoxc9-like mixer msx1 nodal3.1 nodal3.2 nodal5 nodal5.2 nodal5.4 nodal6 nog otx2 pax2 pax6 ppp2r5e ptpa sia1 sox17b.1 vegt ventx1.1 ventx2.1 wnt1
Morpholinos: ppp2r5e MO1


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