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Immunogenetics
2013 Jan 01;651:63-73. doi: 10.1007/s00251-012-0657-6.
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The chicken SLAM family.
Straub C
,
Viertlboeck BC
,
Göbel TW
.
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The signaling lymphocytic activation molecule (SLAM) family of receptors is critically involved in the immune regulation of lymphocytes but has only been detected in mammals, with one member being present in Xenopus. Here, we describe the identification, cloning, and analysis of the chicken homologues to the mammalian SLAMF1 (CD150), SLAMF2 (CD48), and SLAMF4 (CD244, 2B4). Two additional chicken SLAM genes were identified and designated SLAMF3like and SLAM5like in order to stress that those two receptors have no clear mammalian counterpart but share some features with mammalian SLAMF3 and SLAMF5, respectively. Three of the chicken SLAM genes are located on chromosome 25, whereas two are currently not yet assigned. The mammalian and chicken receptors share a common structure with a V-like domain that lacks conserved cysteine residues and a C2-type Ig domain with four cysteines forming two disulfide bonds. Chicken SLAMF2, like its mammalian counterpart, lacks a transmembrane and cytoplasmic domain and thus represents a glycosyl-phosphatidyl-inositol-anchored protein. The cytoplasmic tails of SLAMF1 and SLAMF4 display two and four conserved immunoreceptor tyrosine-based switch motifs (ITSMs), respectively, whereas both chicken SLAMF3like and SLAMF5like have only a single ITSM. We have also identified the chicken homologues of the SLAM-associated protein family of adaptors (SAP), SAP and EAT-2. Chicken SAP shares about 70 % identity with mammalian SAP, and chicken EAT-2 is homologous to mouse EAT-2, whereas human EAT-2 is much shorter. The characterization of the chicken SLAM family of receptors and the SAP adaptors demonstrates the phylogenetic conservation of this family, in particular, its signaling capacities.
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997, Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Bendtsen,
Improved prediction of signal peptides: SignalP 3.0.
2004,
Pubmed
Boles,
2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes.
2001,
Pubmed
Cannons,
SLAM family receptors and SAP adaptors in immunity.
2011,
Pubmed
Colonna,
Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors.
1997,
Pubmed
Daëron,
Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future.
2008,
Pubmed
Dong,
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
2012,
Pubmed
Guselnikov,
Expansion and diversification of the signaling capabilities of the CD2/SLAM family in Xenopodinae amphibians.
2011,
Pubmed
,
Xenbase
Göbel,
Expression of an avian CD6 candidate is restricted to alpha beta T cells, splenic CD8+ gamma delta T cells and embryonic natural killer cells.
1996,
Pubmed
Göbel,
Avian natural killer cells.
1996,
Pubmed
Göbel,
The chicken TCR zeta-chain restores the function of a mouse T cell hybridoma.
1998,
Pubmed
Kageyama,
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.
2012,
Pubmed
Letunic,
SMART 7: recent updates to the protein domain annotation resource.
2012,
Pubmed
Long,
Regulation of immune responses through inhibitory receptors.
1999,
Pubmed
Neulen,
Identification of a chicken CLEC-2 homologue, an activating C-type lectin expressed by thrombocytes.
2012,
Pubmed
Nimmerjahn,
Fcgamma receptors as regulators of immune responses.
2008,
Pubmed
Odorizzi,
Inhibitory receptors on lymphocytes: insights from infections.
2012,
Pubmed
Ravetch,
Immune inhibitory receptors.
2000,
Pubmed
Reth,
Antigen receptor tail clue.
1989,
Pubmed
Rhee,
Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.
2012,
Pubmed
Rogers,
Avian NK activities, cells and receptors.
2008,
Pubmed
Schultz,
SMART, a simple modular architecture research tool: identification of signaling domains.
1998,
Pubmed
Shlapatska,
CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.
2001,
Pubmed
Sidorenko,
The dual-function CD150 receptor subfamily: the viral attraction.
2003,
Pubmed
Tamura,
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.
2007,
Pubmed
Veillette,
SLAM-family receptors: immune regulators with or without SAP-family adaptors.
2010,
Pubmed
Viertlboeck,
The chicken leukocyte receptor complex: a highly diverse multigene family encoding at least six structurally distinct receptor types.
2005,
Pubmed
Viertlboeck,
The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L.
2006,
Pubmed
Viertlboeck,
The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor.
2007,
Pubmed
Viertlboeck,
A novel activating chicken IgY FcR is related to leukocyte receptor complex (LRC) genes but is located on a chromosomal region distinct from the LRC and FcR gene clusters.
2009,
Pubmed
Viertlboeck,
The chicken leukocyte receptor cluster.
2011,
Pubmed
Viertlboeck,
Chicken thrombocytes express the CD51/CD61 integrin.
2007,
Pubmed
Viertlboeck,
Characterization of the chicken CD200 receptor family.
2008,
Pubmed
Viertlboeck,
Chicken Ig-like receptor B2, a member of a multigene family, is mainly expressed on B lymphocytes, recruits both Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 and SHP-2, and inhibits proliferation.
2004,
Pubmed
Zhao,
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
2012,
Pubmed
Zhu,
Cell surface signaling molecules in the control of immune responses: a tide model.
2011,
Pubmed
