XB-ART-46238
FEBS Lett
2012 Dec 14;58624:4276-81. doi: 10.1016/j.febslet.2012.10.046.
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Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin.
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TRPN1 is a candidate mechanotransduction channel in Drosophila and Caenorhabditis elegans, also present in hair cells of lower vertebrates. At its N-terminal cytoplasmic tail it contains 28 ankyrin repeats. We performed a yeast two-hybrid screen with the N-terminal ankyrin repeats of Xenopus TRPN1 as bait and identified the Penta-EF-hand protein peflin as a putative interaction partner. We confirmed this interaction by GST pulldown assays and by co-localization in an epithelial cell model. Collectively, our study identifies peflin as an interaction partner of TRPN1 in vitro.
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Species referenced: Xenopus laevis
Genes referenced: ank1 XB5813854