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XB-ART-46504
Genome Biol October 22, 2012; 13 (10): 251.

The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.

Schmidt R , Plath K .


Abstract
ABSTRACT: Somatic cell reprogramming to induced pluripotent stem (iPS) cells by defined factors is a form of engineered reverse development carried out in vitro. Recent investigation has begun to elucidate the molecular mechanisms whereby these factors function to reset the epigenome.

PubMed ID: 23088445
PMC ID: PMC3491406
Article link: Genome Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: dpy30 isyna1 klf4 pou5f3.1 smarcc1 smarcc2 sox2 taf5 taf6 taf7 tbp tbx2 wdr5


Article Images: [+] show captions
References [+] :
Ahmed, Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. 2010, Pubmed